Griffin, a stand-up comic and actor, best known for his sitcom "Malcom & Eddie," was onstage at when a woman in the audience threw her drink at him, according to TMZ reports.
Griffin, in turn, emptied his water bottle on her, TMZ reported.
The was called, but club security had already ejected the woman from the scene, TMZ said.
The comedy club then closed for the night, and no arrests were made, the network reported.
The incident was captured on video: http://www.youtube.com/watch?v=ijfvc_EBeck.